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Anoikis mechanisms. Frisch SM, Screaton RA. Curr Opin Cell Biol. 2001 Oct;13(5):555-62. Review.

The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. sfrisch@burnham-inst.org

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.